Region-free. Will work on UK/EUR/US consoles.
This was an exclusive title to Japan in the 90's which has now been custom made to be compatible on your console.
The game is a pseudo-3D scrolling shooter, with similar gameplay to that of Space Harrier.
It's set in an anime-style fantasy world where you can move Cotton over the screen, shooting at oncoming enemies and avoiding obstacles on her way. Cotton can upgrade her weapon to higher levels as you advance in the game, and can also cast magical spells by collecting special items.
The menu and gameplay is in English, but the narrative is still in Japanese.